Liberated, But Not Free

not intervention but participation

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A fragment liberated from the Escherichia coli CheA kinase that blocks stimulatory, but not inhibitory, chemoreceptor signaling.

CheA, a cytoplasmic histidine autokinase, in conjunction with the CheW coupling protein, forms stable ternary complexes with the cytoplasmic signaling domains of transmembrane chemoreceptors. These signaling complexes induce chemotactic movements by stimulating or inhibiting CheA autophosphorylation activity in response to chemoeffector stimuli. To explore the mechanisms of CheA control by chem...

trigeminal neuralgia-divided but not classified

Open but not free--publishing in the 21st century.

787 Research culture is far from monolithic. Systems that underpin scholarly communication will migrate to open access by fits and starts as discipline-appropriate options emerge. Meanwhile, experiments will be run, start-ups will flourish or perish, and new communication tools will emerge, because, as the Bethesda Open Access Statement puts it, “an old tradition and a new technology have conve...

From the Editor in Chief: Not Free, But Relatively Inexpensive

Ihave many hats. For my day job, I hang out at NASA and try to figure out how to simplify building software for flying things. In my copious free time, I’m a journalist. This entitles me to do things like attend conferences as “press” (the power of the media being such that one is sometimes better treated than the paying attendees), write this column, and worry about how all this great Internet...